Multiple endocrine neoplasia type 1 (MEN1) is a hereditary tumor syndrome characterized by tumors of the parathyroid glands, the pancreatic islets, the pituitary gland, the adrenal glands, as well as ...

Menin, a transcriptional scaffold protein, regulates pancreatic beta cell homeostasis; inhibiting menin function with BMF-219 increased beta cell function in a preclinical animal model, driving an ...

Menin acts as a ‘brake’ on beta cell regeneration; inhibiting menin function with BMF-219 may increase beta cell production and function, thereby increasing insulin levels and controlling high glucose ...

Researchers at the University of Pennsylvania School of Medicine have found that the acute loss of a protein called menin can cause the proliferation of pancreatic islet cells, which secrete insulin ...

Acute loss of a protein named menin - involved in tumor-suppression or cell-proliferation-suppressing function resulted in the proliferation of pancreatic islet cells, which again affected blood sugar ...

In this study, we focused on the analysis of the in vitro expression of MEN1 mRNA and menin in primary cell cultures from both healthy fibroblasts and fibroblasts obtained from MEN1 patients using RNA ...

Scientists from the Australian National University (ANU) and the Peter MacCallum Cancer Centre have discovered in mice that a protein, called Menin, contributes to abnormal deactivation of specific ...

Scientists from The Australian National University (ANU) and the Peter MacCallum Cancer Centre have discovered that a protein, called Menin, contributes to abnormal deactivation of specific genes in ...

Scientists from The Australian National University (ANU) and the Peter MacCallum Cancer Centre have discovered that a protein, called Menin, contributes to abnormal deactivation of specific genes in ...

Menin inhibitors target the interaction between menin and the KMT2A complex, offering a breakthrough in treating acute leukemias with specific genetic mutations. Monotherapy with menin inhibitors ...

Scientists from The Australian National University (ANU) and the Peter MacCallum Cancer Centre have discovered that a protein, called Menin, contributes to abnormal deactivation of specific genes in ...