Update on SORL1: Trafficking is Paramount, in Neurons and …
Jan 17, 2025 · Yet, SORL1 gets plenty busy in microglia, as well, albeit on a different set of tasks, namely, supporting the lysosome. Previously, Young and colleagues found that while SORL1 …
After Immunotherapy, Amyloid Clearance Comes Down to …
Mar 14, 2025 · Microglia also took on distinct signatures depending on the extent of amyloid clearance in their neighborhood. For example, in cases of extensive plaque clearance, the …
TREM2: A Chill Pill for Neurons? | ALZFORUM
Apr 17, 2025 · The microglia then use a cell-specific ATP/ADP hydrolyzing ectoenzyme called CD39 to convert the ATP into AMP, which is then hydrolyzed to adenosine via CD73 receptors …
Moving Target: New Biology Casts TREM2 as a Shifty Mark
Apr 17, 2025 · For one, microglia hovering around plaques—the type that express the most TREM2—reportedly become desensitized to stimulation by TREM2 agonist antibodies. This …
Microglia protect against age-associated brain pathologies
Jun 28, 2024 · Both papers agree that the lack of microglia in adult mice results in neurodegeneration, brain calcifications, and myelin abnormalities, phenotypes resembling …
VHB937 | ALZFORUM
Jun 6, 2025 · VHB937 is a humanized monoclonal antibody to the immune receptor TREM2. TREM2 activation stimulates proliferation and phagocytic function of microglia, which play a …
Expunging Microglial Lipid Droplets Boosts Phagocytosis
Feb 12, 2025 · Wu and colleagues confirmed that cultured-microglia-carrying lipid droplets struggled with phagocytosis, poorly engulfing fluorescently labeled inactivated E. Coli or Aβ. …
Microglia Build Plaques to Protect the Brain - ALZFORUM
Apr 22, 2021 · Could it be that microglia build plaques rather than bust them? In the April 15 Nature Immunology, researchers led by Greg Lemke at the Salk Institute for Biological …
Reducing microglial lipid load enhances β amyloid phagocytosis in …
Feb 12, 2025 · Tony Wyss-Coray Stanford University Medical School Andy Tsai Stanford University Posted: 07 Feb 2025 News: Expunging Microglial Lipid Droplets Boosts …
Protective Microglia Unmasked: They Act Like Regulatory T Cells
Nov 13, 2025 · PU.1-low microglia were rare, making up less than 1 percent of the total. To a “T.” A subtype of regulatory microglia express many of the immunomodulatory receptors typically …