Update on SORL1: Trafficking is Paramount, in Neurons and Microglia
Jan 17, 2025 · Yet, SORL1 gets plenty busy in microglia, as well, albeit on a different set of tasks, namely, supporting the lysosome. Previously, Young and colleagues found that while SORL1 …
Expunging Microglial Lipid Droplets Boosts Phagocytosis
Feb 12, 2025 · Wu and colleagues confirmed that cultured-microglia-carrying lipid droplets struggled with phagocytosis, poorly engulfing fluorescently labeled inactivated E. Coli or Aβ. What if microglia …
After Immunotherapy, Amyloid Clearance Comes Down to Microglial …
Mar 14, 2025 · Microglia also took on distinct signatures depending on the extent of amyloid clearance in their neighborhood. For example, in cases of extensive plaque clearance, the cells upregulated …
TREM2: A Chill Pill for Neurons? | ALZFORUM
Apr 17, 2025 · The microglia then use a cell-specific ATP/ADP hydrolyzing ectoenzyme called CD39 to convert the ATP into AMP, which is then hydrolyzed to adenosine via CD73 receptors expressed by …
Protective Microglia Unmasked: They Act Like Regulatory T Cells
Nov 13, 2025 · PU.1-low microglia were rare, making up less than 1 percent of the total. To a “T.” A subtype of regulatory microglia express many of the immunomodulatory receptors typically found on …
Microglia protect against age-associated brain pathologies
Jun 28, 2024 · Both papers agree that the lack of microglia in adult mice results in neurodegeneration, brain calcifications, and myelin abnormalities, phenotypes resembling CSF1R-related …
Moving Target: New Biology Casts TREM2 as a Shifty Mark
Apr 17, 2025 · For one, microglia hovering around plaques—the type that express the most TREM2—reportedly become desensitized to stimulation by TREM2 agonist antibodies. This …
PILRA regulates microglial neuroinflammation and lipid ... - ALZFORUM
Jul 19, 2024 · PILRA knockout microglia display lipid droplet accumulation but maintain homeostasis in an inflammatory environment by showing increased lipid-APOE uptake, enhanced mitochondria …
Breaking the Spell: Checkpoint Inhibitors Help Microglia Snap Out of It
May 7, 2025 · All the things that define AD pathogenesis—the seeding and growth of Aβ plaques, withering of surrounding synapses, propagation of tau tangles, and infiltration of circulating immune …
VHB937 | ALZFORUM
Jun 6, 2025 · VHB937 is a humanized monoclonal antibody to the immune receptor TREM2. TREM2 activation stimulates proliferation and phagocytic function of microglia, which play a central role in …