p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often …

This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered. The p53 pathway is a complex cellular stress response network with …

The p53 gene, also known as TP53, is located on chromosome 17. It produces the p53 protein, which plays a crucial role in maintaining cellular stability and normal biological processes.

Mar 1, 2023 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss key …

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing …

p53 p53 is a tumor suppressor gene and is commonly mutated in several human cancers. In routine diagnostic surgical pathology, mutation status is assessed based on p53 expression by IHC.

Jun 15, 2025 · At the heart of this defense is a protein known as p53, often called the “guardian of the genome.” This protein is a component of a pathway that responds to cellular stress, working to keep …

The perturbation of p53 signaling pathways is required for the development of most cancers; however, it is now becoming clear that p53 has a much broader role in human health and diseases.

Apr 9, 2025 · This Review discusses the roles, mechanisms and physiological settings in which NACDs are regulated by p53, and their potential targeting for the treatment of human diseases.

In this review, we describe and discuss the multifaceted roles of p53, from its discovery to clinical applications in cancer therapy. p53 tumour suppressor gene is our major barrier against neoplastic …